The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

Here we showed that hepatocellular carcinoma (HCC) cell lines with high metastatic potential had low levels of NDRG2. The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having high metastatic potential. Also Dp44mT at...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Jiabei, Yin, Dalong, Xie, Changming, Zheng, Tongsen, Liang, Yingjian, Hong, Xuehui, Lu, Zhaoyang, Song, Xuan, Song, Ruipeng, Yang, Haiyan, Sun, Boshi, Bhatta, Nishant, Meng, Xianzhi, Pan, Shangha, Jiang, Hongchi, Liu, Lianxin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226698/
https://ncbi.nlm.nih.gov/pubmed/25261367
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