FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling

BACKGROUND: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. FTY720, a new immunos...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Lu, Zhaoyang, Wang, Jiabei, Zheng, Tongsen, Liang, Yingjian, Yin, Dalong, Song, Ruipeng, Pei, Tiemin, Pan, Shangha, Jiang, Hongchi, Liu, Lianxin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221672/
https://ncbi.nlm.nih.gov/pubmed/25344679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-783
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