Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma

BACKGROUND: Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide was poorly effective against hepatocellular carcinoma (HCC), which might be...

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Detalhes bibliográficos
Main Authors: Zheng, Tongsen, Yin, Dalong, Lu, Zhaoyang, Wang, Jiabei, Li, Yuejin, Chen, Xi, Liang, Yingjian, Song, Xuan, Qi, Shuyi, Sun, Boshi, Xie, Changming, Meng, Xianzhi, Pan, Shangha, Liu, Jiaren, Jiang, Hongchi, Liu, Lianxin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046148/
https://ncbi.nlm.nih.gov/pubmed/24884809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-133
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