Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

We developed a systematic algorithmic solution for quantitative drug sensitivity scoring (DSS), based on continuous modeling and integration of multiple dose-response relationships in high-throughput compound testing studies. Mathematical model estimation and continuous interpolation makes the scori...

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Detalhes bibliográficos
Main Authors: Yadav, Bhagwan, Pemovska, Tea, Szwajda, Agnieszka, Kulesskiy, Evgeny, Kontro, Mika, Karjalainen, Riikka, Majumder, Muntasir Mamun, Malani, Disha, Murumägi, Astrid, Knowles, Jonathan, Porkka, Kimmo, Heckman, Caroline, Kallioniemi, Olli, Wennerberg, Krister, Aittokallio, Tero
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046135/
https://ncbi.nlm.nih.gov/pubmed/24898935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05193
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