Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progression

Viral escape from HIV-1-specific CD8(+) T cells has been demonstrated in numerous studies previously. However, the qualitative features driving the emergence of mutations within epitopes are still unclear. In this study, we aimed to distinguish whether specific functional characteristics of HLA-B*57...

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Bibliographic Details
Main Authors: Buggert, Marcus, Norström, Melissa M, Salemi, Marco, Hecht, Frederick M, Karlsson, Annika C
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046013/
https://ncbi.nlm.nih.gov/pubmed/24740510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302253
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