Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells

Long-term activation of extracellular-regulated kinase (ERK1/2) pathway has been shown to cause glucotoxicity and inhibit insulin gene expression in β-cells. Transcription factor Ets1 is activated by ERK1/2-mediated phosphorylation at the Thr38 residue. We hypothesize that Ets1 plays an important ro...

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מידע ביבליוגרפי
Main Authors: Luo, Yan, He, Fengli, Hu, Li, Hai, Luo, Huang, Meifeng, Xu, Zhipeng, Zhang, Jingjing, Zhou, Zhiguang, Liu, Feng, Dai, Yan-Shan
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045976/
https://ncbi.nlm.nih.gov/pubmed/24897113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099049
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