Pancreatic β-cell Enhancers Regulate Rhythmic Transcription of Genes Controlling Insulin Secretion

The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle. Genetic or environmental perturbation of circadian cycles contributes to metabolic disorders including type 2 diabetes. To study the impac...

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發表在:Science
Main Authors: Perelis, Mark, Marcheva, Biliana, Ramsey, Kathryn Moynihan, Schipma, Matthew J., Hutchison, Alan L., Taguchi, Akihiko, Peek, Clara Bien, Hong, Heekyung, Huang, Wenyu, Omura, Chiaki, Allred, Amanda L., Bradfield, Christopher A., Dinner, Aaron R., Barish, Grant D., Bass, Joseph
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669216/
https://ncbi.nlm.nih.gov/pubmed/26542580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac4250
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