Pancreatic β-cell Enhancers Regulate Rhythmic Transcription of Genes Controlling Insulin Secretion

The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle. Genetic or environmental perturbation of circadian cycles contributes to metabolic disorders including type 2 diabetes. To study the impac...

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Publicado en:Science
Main Authors: Perelis, Mark, Marcheva, Biliana, Ramsey, Kathryn Moynihan, Schipma, Matthew J., Hutchison, Alan L., Taguchi, Akihiko, Peek, Clara Bien, Hong, Heekyung, Huang, Wenyu, Omura, Chiaki, Allred, Amanda L., Bradfield, Christopher A., Dinner, Aaron R., Barish, Grant D., Bass, Joseph
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669216/
https://ncbi.nlm.nih.gov/pubmed/26542580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac4250
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