Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

The alignment of fasting and feeding with the sleep/ wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eating during wakefulness and glucose production during...

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Pubblicato in:Cell Metab
Autori principali: Cedernaes, Jonathan, Huang, Wenyu, Ramsey, Kathryn Moynihan, Waldeck, Nathan, Cheng, Lei, Marcheva, Biliana, Omura, Chiaki, Kobayashi, Yumiko, Peek, Clara Bien, Levine, Daniel C., Dhir, Ravindra, Awatramani, Raj, Bradfield, Christopher A., Wang, Xiaozhong A., Takahashi, Joseph S., Mokadem, Mohamad, Ahima, Rexford S., Bass, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506361/
https://ncbi.nlm.nih.gov/pubmed/30827863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.01.023
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