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SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells
SPARC-deficient mice have been shown to exhibit impaired glucose tolerance and insulin secretion, but the underlying mechanism remains unknown. Here, we showed that SPARC enhanced the promoting effect of Muscarinic receptor agonist oxotremorine-M on insulin secretion in cultured mouse islets. Overex...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7567887/ https://ncbi.nlm.nih.gov/pubmed/33067534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74593-w |
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