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CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7

Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic adapter protein β-arrestin 2. Differences in CXCL12...

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Detalhes bibliográficos
Main Authors: Coggins, Nathaniel L., Trakimas, Danielle, Chang, S. Laura, Ehrlich, Anna, Ray, Paramita, Luker, Kathryn E., Linderman, Jennifer J., Luker, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045718/
https://ncbi.nlm.nih.gov/pubmed/24896823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098328
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