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Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
Given that most bone marrow cells are short-lived, the accumulation of multiple leukemogenic mutations in a single clonal lineage has been difficult to explain. Here, we propose that serial acquisition of mutations occurs in self-renewing hematopoietic stem cells (HSCs). We investigated this model t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4045621/ https://ncbi.nlm.nih.gov/pubmed/22932223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004315 |
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