Chargement en cours...
Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
Given that most bone marrow cells are short-lived, the accumulation of multiple leukemogenic mutations in a single clonal lineage has been difficult to explain. Here, we propose that serial acquisition of mutations occurs in self-renewing hematopoietic stem cells (HSCs). We investigated this model t...
Enregistré dans:
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4045621/ https://ncbi.nlm.nih.gov/pubmed/22932223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004315 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|