The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

Mips (macrophage infectivity potentiators) are a subset of immunophilins associated with virulence in a range of micro-organisms. These proteins possess peptidylprolyl isomerase activity and are inhibited by drugs including rapamycin and tacrolimus. We determined the structure of the Mip homologue [...

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Bibliographische Detailangaben
Hauptverfasser: Norville, Isobel H., O'Shea, Katherine, Sarkar-Tyson, Mitali, Zheng, Suxin, Titball, Richard W., Varani, Gabriele, Harmer, Nicholas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045482/
https://ncbi.nlm.nih.gov/pubmed/21574961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110345
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