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Unusual Characteristics of the DNA Binding Domain of Epigenetic Regulatory Protein MeCP2 Determine Its Binding Specificity

[Image: see text] The protein MeCP2 mediates epigenetic regulation by binding methyl-CpG (mCpG) sites on chromatin. MeCP2 consists of six domains of which one, the methyl binding domain (MBD), binds mCpG sites in duplex DNA. We show that solution conditions with physiological or greater salt concent...

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Detalhes bibliográficos
Main Authors: Khrapunov, Sergei, Warren, Christopher, Cheng, Huiyong, Berko, Esther R., Greally, John M., Brenowitz, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045320/
https://ncbi.nlm.nih.gov/pubmed/24828757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500424z
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