Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)

BACKGROUND: α/β-hydrolase domain containing (ABHD)12 is a recently discovered serine hydrolase that acts in vivo as a lysophospholipase for lysophosphatidylserine. Dysfunctional ABHD12 has been linked to the rare neurodegenerative disorder called PHARC (polyneuropathy, hearing loss, ataxia, retinosi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Parkkari, Teija, Haavikko, Raisa, Laitinen, Tuomo, Navia-Paldanius, Dina, Rytilahti, Roosa, Vaara, Miia, Lehtonen, Marko, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Nevalainen, Tapio, Savinainen, Juha R., Laitinen, Jarmo T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045134/
https://ncbi.nlm.nih.gov/pubmed/24879289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098286
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi