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Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A
[Image: see text] Screening of an in-house library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the 2-methylthiazole derivative 18, with an IC(50) value of 3.4 ± 0...
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| 發表在: | ACS Med Chem Lett |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2018
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6296171/ https://ncbi.nlm.nih.gov/pubmed/30613338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00442 |
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