Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors ()

At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the optimization of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds were synthesized and their inhibitory activ...

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Published in:ChemMedChem
Main Authors: Patel, Jayendra Z., Nevalainen, Tapio J., Savinainen, Juha R., Adams, Yahaya, Laitinen, Tuomo, Runyon, Robert S., Vaara, Miia, Ahenkorah, Stephen, Kaczor, Agnieszka A., Navia-Paldanius, Dina, Gynther, Mikko, Aaltonen, Niina, Joharapurkar, Amit A., Jain, Mukul R., Haka, Abigail S., Maxfield, Frederick R., Laitinen, Jarmo T., Parkkari, Teija
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471478/
https://ncbi.nlm.nih.gov/pubmed/25504894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402453
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