The Chaperone-Like Activity of α-Synuclein Attenuates Aggregation of Its Alternatively Spliced Isoform, 112-Synuclein In Vitro: Plausible Cross-Talk between Isoforms in Protein Aggregation

Abnormal oligomerization and aggregation of α-synuclein (α-syn/WT-syn) has been shown to be a precipitating factor in the pathophysiology of Parkinson's disease (PD). Earlier observations on the induced-alternative splicing of α-syn by Parkinsonism mimetics as well as identification of region s...

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Main Authors: Manda, Krishna Madhuri, Yedlapudi, Deepthi, Korukonda, Srikanth, Bojja, Sreedhar, Kalivendi, Shasi V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043908/
https://ncbi.nlm.nih.gov/pubmed/24892822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098657
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