A role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia and mortality

OBJECTIVE: Poor prognosis of sepsis is associated with bacterial lipopolysaccharide (LPS)-induced intravascular inflammation, microvascular thrombosis, thrombocytopenia, and disseminated intravascular coagulation. Platelets are critical for thrombosis, and there have been increasing evidence of the...

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Autori principali: Yin, Hong, Stojanovic, Aleksandra, Xu, Weidong, Corken, Adam, Zakharov, Alexander, Qian, Feng, Pavlovic, Sasha, Krbanjevic, Aleksandar, Lyubimov, Alexander V., Wang, Zaijie J., Ware, Jerry, Du, Xiaoping
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043446/
https://ncbi.nlm.nih.gov/pubmed/24051142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302339
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