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Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells
OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy. METHODS: The cyp4B1 cDNA was cloned into pcDNA3.1/Hygro from rabbi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042932/ https://ncbi.nlm.nih.gov/pubmed/24899949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13139-010-0038-8 |
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