Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells

OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy. METHODS: The cyp4B1 cDNA was cloned into pcDNA3.1/Hygro from rabbi...

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Autores principales: Jang, Su Jin, Kang, Joo Hyun, Lee, Tae Sup, Kim, Sung Joo, Kim, Kwang Il, Lee, Yong Jin, Cheon, Gi Jeong, Choi, Chang Woon, Lim, Sang Moo
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer-Verlag 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042932/
https://ncbi.nlm.nih.gov/pubmed/24899949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13139-010-0038-8
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