Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML

Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive to nuclear factor κB (NF-κB) inhibition-induced cell death when compared with hematopoietic stem and progenitor cells (HSPCs) in in vitro culture. However, inadequate anti-leukemic activity of NF-κB inh...

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Hauptverfasser: Volk, Andrew, Li, Jing, Xin, Junping, You, Dewen, Zhang, Jun, Liu, Xinli, Xiao, Yechen, Breslin, Peter, Li, Zejuan, Wei, Wei, Schmidt, Rachel, Li, Xingyu, Zhang, Zhou, Kuo, Paul C., Nand, Sucha, Zhang, Jianke, Chen, Jianjun, Zhang, Jiwang
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042653/
https://ncbi.nlm.nih.gov/pubmed/24842373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130990
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