Sensitizing Acute Myeloid Leukemia Cells to Induced Differentiation by Inhibiting the RIP1/RIP3 Pathway

Tumor necrosis factor-α (TNF)-induced RIP1/RIP3-mediated necroptosis has been proposed to be an alternative strategy for treating apoptosis-resistant leukemia. However, we found that most acute myeloid leukemia (AML) cells, especially M4 and M5 subtypes, produce TNF and show basal level activation o...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Xin, Junping, You, Dewen, Breslin, Peter, Li, Jing, Zhang, Jun, Wei, Wei, Cannova, Joseph, Volk, Andrew, Gutierrez, Rafael, Xiao, Yechen, Ni, Allen, Ng, Grace, Schmidt, Rachel, Xia, Zhixin, Pan, Jerry, Chen, Haiyan, Patel, Malini M., Kuo, Paul C, Nand, Sucha, Kini, Ameet R, Zhang, Jianke, Chen, Jianjun, Zhu, Jiang, Zhang, Jiwang
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457287/
https://ncbi.nlm.nih.gov/pubmed/27748372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.287
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