Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling

We previously reported that autocrine TNF-α (TNF) is responsible for JNK pathway activation in a subset of acute myeloid leukemia (AML) patient samples, providing a survival/proliferation signaling parallel to NF-κB in AML stem cells (LSCs). In this study, we report that most TNF-expressing AML cell...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Jing, Volk, Andrew, Zhang, Jun, Cannova, Joseph, Dai, Shaojun, Hao, Caiqin, Hu, Chenglong, Sun, Jiewen, Xu, Yan, Wei, Wei, Breslin, Peter, Nand, Sucha, Chen, Jianjun, Kini, Ameet, Zhu, Jiang, Zhang, Jiwang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352411/
https://ncbi.nlm.nih.gov/pubmed/28039479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14220
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