Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity

B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of t...

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Bibliographic Details
Main Authors: Sun, Jianbo, Rothschild, Gerson, Pefanis, Evangelos, Basu, Uttiya
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042586/
https://ncbi.nlm.nih.gov/pubmed/23584095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.24556
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