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Transcriptional stalling in B-lymphocytes: A mechanism for antibody diversification and maintenance of genomic integrity
B cells utilize three DNA alteration strategies—V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)—to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of t...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Landes Bioscience
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042586/ https://ncbi.nlm.nih.gov/pubmed/23584095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.24556 |
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