Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity

A loss of glucose effectiveness to suppress hepatic glucose production as well as increase hepatic glucose uptake and storage as glycogen is associated with a defective increase in glucose phosphorylation catalyzed by glucokinase (GK) in Zucker diabetic fatty (ZDF) rats. We extended these observatio...

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Hauptverfasser: Ueta, Kiichiro, O'Brien, Tracy P., McCoy, Gregory A., Kim, Kuikwon, Healey, Erin C., Farmer, Tiffany D., Donahue, E. Patrick, Condren, Audree B., Printz, Richard L., Shiota, Masakazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042096/
https://ncbi.nlm.nih.gov/pubmed/24714398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00507.2013
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