Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system

CRISPR-Cas is an adaptive prokaryotic immune system, providing protection against viruses and other mobile genetic elements. In type I and type III CRISPR-Cas systems, CRISPR RNA (crRNA) is generated by cleavage of a primary transcript by the Cas6 endonuclease and loaded into multisubunit surveillan...

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Bibliographic Details
Main Authors: Sokolowski, Richard D., Graham, Shirley, White, Malcolm F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041471/
https://ncbi.nlm.nih.gov/pubmed/24753403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku308
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