Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association

The Saccharomyces cerevisiae Rad1-Rad10 complex is a conserved, structure-specific endonuclease important for repairing multiple types of DNA lesions. Upon recruitment to lesion sites, Rad1-Rad10 removes damaged sequences, enabling subsequent gap filling and ligation. Acting at mid-steps of repair,...

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Détails bibliographiques
Auteurs principaux: Sarangi, Prabha, Bartosova, Zdenka, Altmannova, Veronika, Holland, Cory, Chavdarova, Melita, Lee, Sang Eun, Krejci, Lumir, Zhao, Xiaolan
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041466/
https://ncbi.nlm.nih.gov/pubmed/24753409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku300
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