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5-Fluorouracil affects assembly of stress granules based on RNA incorporation

The antimetabolite 5-fluorouracil is a widely used chemotherapeutic for the treatment of several solid cancers. However, resistance to 5-fluorouracil remains a major drawback in its clinical use. In this study we report that treatment of HeLa cells with 5-fluorouracil resulted in de novo assembly of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kaehler, Christian, Isensee, Jörg, Hucho, Tim, Lehrach, Hans, Krobitsch, Sylvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041438/
https://ncbi.nlm.nih.gov/pubmed/24728989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku264
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