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SOCS3 Deletion in T-Lymphocytes Suppresses Development of Chronic Ocular Inflammation Via Up-regulation of CTLA-4 and Expansion of Regulatory T cells

Suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of JAK/STAT pathway and SOCS3 contributes to host immunity by regulating the intensity/duration of cytokine signals and inflammatory responses. Mice with Socs3 deletion in myeloid cells exhibit enhanced STAT3-signalin...

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Bibliografiske detaljer
Main Authors: Yu, Cheng-Rong, Kim, Sung-Hye, Mahdi, Rashid M., Egwuagu, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041279/
https://ncbi.nlm.nih.gov/pubmed/24101549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301132
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