Coordination of peroxide to the Cu(M) center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study

Many bioactive peptides, such as hormones and neuropeptides, require amidation at the C terminus for their full biological activity. Peptidylglycine α-hydroxylating monooxygenase (PHM) performs the first step of the amidation reaction—the hydroxylation of peptidylglycine substrates at the Cα positio...

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Hlavní autoři: Rudzka, Katarzyna, Moreno, Diego M., Eipper, Betty, Mains, Richard, Estrin, Dario A., Amzel, L. Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041156/
https://ncbi.nlm.nih.gov/pubmed/23247335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-012-0967-z
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