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The genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors

The epoxyketone proteasome inhibitors are an established class of therapeutic agents for the treatment of cancer. Their unique α′,β′-epoxyketone pharmacophore allows binding to the catalytic β-subunits of the proteasome with extraordinary specificity. Here we report the characterization of the first...

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Bibliografski detalji
Glavni autori: Schorn, Michelle, Zettler, Judith, Noel, Joseph P., Dorrestein, Pieter C., Moore, Bradley S., Kaysser, Leonard
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041076/
https://ncbi.nlm.nih.gov/pubmed/24168704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400699p
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