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The genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors
The epoxyketone proteasome inhibitors are an established class of therapeutic agents for the treatment of cancer. Their unique α′,β′-epoxyketone pharmacophore allows binding to the catalytic β-subunits of the proteasome with extraordinary specificity. Here we report the characterization of the first...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041076/ https://ncbi.nlm.nih.gov/pubmed/24168704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400699p |
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