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The genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors
The epoxyketone proteasome inhibitors are an established class of therapeutic agents for the treatment of cancer. Their unique α′,β′-epoxyketone pharmacophore allows binding to the catalytic β-subunits of the proteasome with extraordinary specificity. Here we report the characterization of the first...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041076/ https://ncbi.nlm.nih.gov/pubmed/24168704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400699p |
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