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Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and its contributions towards the disposal of 4-hydroxy-2-(E)-nonenal in rat liver
The major route for elimination of 4-hydroxy-2-(E)-nonenal (4-HNE) has long been considered to be through glutathionylation and eventual excretion as a mercapturic acid conjugate. To better quantitate the glutathionylation process, we developed a sensitive LC-MS/MS method for the detection of glutat...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040968/ https://ncbi.nlm.nih.gov/pubmed/24556413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.02.008 |
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