(S)-preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats.

In guinea-pig liver cytosol, racemic 4-hydroxy-2(E)-nonenal (HNE), a reactive and highly toxic product released from biomembranes by lipid peroxidation, was detoxified (S)-preferentially by GSH conjugation mediated by glutathione S-transferases (GSTs) and (R)-preferentially by NAD(+)-dependent oxida...

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Autori principali: Hiratsuka, A, Tobita, K, Saito, H, Sakamoto, Y, Nakano, H, Ogura, K, Nishiyama, T, Watabe, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221732/
https://ncbi.nlm.nih.gov/pubmed/11256969
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