Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile

Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spontaneously or be facilitated by the glutathione S-tr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Behrens, Kelsey A., Jania, Leigh A., Snouwaert, John N., Nguyen, MyTrang, Moy, Sheryl S., Tikunov, Andrey P., Macdonald, Jeffrey M., Koller, Beverly H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867637/
https://ncbi.nlm.nih.gov/pubmed/31747445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225449
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