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Mice Lacking Three Loci Encoding 14 Glutathione Transferase Genes: A Novel Tool for Assigning Function to the GSTP, GSTM, and GSTT Families

Glutathione S-transferases (GSTs) form a superfamily defined by their ability to catalyze the conjugation of glutathione with electrophilic substrates. These enzymes are proposed to play a critical role in protection of cellular components from damage mediated by reactive metabolites. Twenty-two cyt...

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Detalhes bibliográficos
Main Authors: Xiang, Zhidan, Snouwaert, John N., Kovarova, Martina, Nguyen, MyTrang, Repenning, Peter W., Latour, Anne M., Cyphert, Jaime M., Koller, Beverly H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014662/
https://ncbi.nlm.nih.gov/pubmed/24658454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.056481
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