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Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation
It is controversial whether fast-folding proteins can form productive on-pathway intermediates that are more stable than the denatured state because noncovalent intermediates are usually evanescent. Here, we apply the classical criteria for the existence of intermediates: namely, the intermediates f...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404065/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15096617/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401732101 |
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