Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation

It is controversial whether fast-folding proteins can form productive on-pathway intermediates that are more stable than the denatured state because noncovalent intermediates are usually evanescent. Here, we apply the classical criteria for the existence of intermediates: namely, the intermediates f...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Jemth, Per, Gianni, Stefano, Day, Ryan, Li, Bin, Johnson, Christopher M., Daggett, Valerie, Fersht, Alan R.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2004
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404065/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15096617/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401732101
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