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Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome

We used the I-SceI endonuclease to produce DNA double-strand breaks (DSBs) and observed that a fraction of these DSBs were repaired by insertion of sequences, which we termed “templated sequence insertions” (TSIs), derived from distant regions of the genome. These TSIs were derived from genic, retro...

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מידע ביבליוגרפי
Main Authors: Onozawa, Masahiro, Zhang, Zhenhua, Kim, Yoo Jung, Goldberg, Liat, Varga, Tamas, Bergsagel, P. Leif, Kuehl, W. Michael, Aplan, Peter D.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040595/
https://ncbi.nlm.nih.gov/pubmed/24821809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321889111
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