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Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome
We used the I-SceI endonuclease to produce DNA double-strand breaks (DSBs) and observed that a fraction of these DSBs were repaired by insertion of sequences, which we termed “templated sequence insertions” (TSIs), derived from distant regions of the genome. These TSIs were derived from genic, retro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040595/ https://ncbi.nlm.nih.gov/pubmed/24821809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321889111 |
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