Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome

Enterohemorrhagic Escherichia coli (EHEC) is an extracellular pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. The proinflammatory cytokine, interleukin-1β, has been linked to hemolytic uremic syndrome. Here we identify the nucleotide-binding domain and leucine rich repeat con...

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Bibliografiske detaljer
Main Authors: Kailasan Vanaja, Sivapriya, Rathinam, Vijay A. K., Atianand, Maninjay K., Kalantari, Parisa, Skehan, Brian, Fitzgerald, Katherine A., Leong, John M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040571/
https://ncbi.nlm.nih.gov/pubmed/24828532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400075111
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