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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

The formation of amyloid fibrils by the intrinsically disordered protein α-synuclein is a hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of aggregation of this protein we have used in vitro aggregation assays in the presence of preformed seed fibrils to determi...

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Autors principals: Buell, Alexander K., Galvagnion, Céline, Gaspar, Ricardo, Sparr, Emma, Vendruscolo, Michele, Knowles, Tuomas P. J., Linse, Sara, Dobson, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040554/
https://ncbi.nlm.nih.gov/pubmed/24817693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315346111
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