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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
The formation of amyloid fibrils by the intrinsically disordered protein α-synuclein is a hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of aggregation of this protein we have used in vitro aggregation assays in the presence of preformed seed fibrils to determi...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040554/ https://ncbi.nlm.nih.gov/pubmed/24817693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315346111 |
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