Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few known targetable genetic alterations. Using genome sequencing, we characterized the somatic evolution of a genetically engineered mouse model (GEMM) of SCLC initiated by loss of Trp53 and Rb1. We identified alter...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: McFadden, David G., Papagiannakopoulos, Thales, Taylor-Weiner, Amaro, Stewart, Chip, Carter, Scott L., Cibulskis, Kristian, Bhutkar, Arjun, McKenna, Aaron, Dooley, Alison, Vernon, Amanda, Sougnez, Carrie, Malstrom, Scott, Heimann, Megan, Park, Jennifer, Chen, Frances, Farago, Anna F., Dayton, Talya, Shefler, Erica, Gabriel, Stacey, Getz, Gad, Jacks, Tyler
التنسيق: Artigo
اللغة:Inglês
منشور في: 2014
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040459/
https://ncbi.nlm.nih.gov/pubmed/24630729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.02.031
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