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Identification and characterization of small molecules that inhibit nonsense mediated RNA decay and suppress nonsense p53 mutations

Many of the gene mutations found in genetic disorders, including cancer, result in premature termination codons (PTCs) and the rapid degradation of their mRNAs by nonsense mediated RNA decay (NMD). We used virtual library screening (VLS) targeting a pocket in the SMG7 protein, a key component of the...

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書誌詳細
主要な著者: Martin, Leenus, Grigoryan, Arsen, Wang, Ding, Wang, Jinhua, Breda, Laura, Rivella, Stefano, Cardozo, Timothy, Gardner, Lawrence B.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040335/
https://ncbi.nlm.nih.gov/pubmed/24662918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2235
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