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Predicted disorder-to-order transition mutations in IκBα disrupt function
IκBα inhibits the transcription factor, NFκB, by forming a very tightly bound complex in which the ankyrin repeat domain (ARD) of IκBα interacts primarily with the dimerization domain of NFκB. The first four ankyrin repeats (ARs) of the IκBα ARD are well-folded, but the AR5-6 region is intrinsically...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040282/ https://ncbi.nlm.nih.gov/pubmed/24605363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cp54427c |
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