Desmin Aggregate Formation by R120G αB-Crystallin Is Caused by Altered Filament Interactions and Is Dependent upon Network Status in Cells

The R120G mutation in αB-crystallin causes desmin-related myopathy. There have been a number of mechanisms proposed to explain the disease process, from altered protein processing to loss of chaperone function. Here, we show that the mutation alters the in vitro binding characteristics of αB-crystal...

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Hlavní autoři: Der Perng, Ming, Wen, Shu Fang, van den IJssel, Paul, Prescott, Alan R., Quinlan, Roy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2004
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC404027/
https://ncbi.nlm.nih.gov/pubmed/15004226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0893
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