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Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor
The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the “bottom-up” design of a small molecule inhibitor of oncogenic microRNA-10b.
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040211/ https://ncbi.nlm.nih.gov/pubmed/24503738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc00173c |
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