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Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the “bottom-up” design of a small molecule inhibitor of oncogenic microRNA-10b.

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Detalles Bibliográficos
Autores principales: Velagapudi, Sai Pradeep, Disney, Matthew D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040211/
https://ncbi.nlm.nih.gov/pubmed/24503738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc00173c
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